Oral care composition comprising cannabinoids

ABSTRACT

This application discloses oral care compositions comprising cannabinoids, preferably cannabidiol and/or cannabigerol. The oral care composition disclosed in this application may be a tooth paste, a tooth powder, or a mouthwash solution. The oral care composition may be used to treat oral infectious disease, including periimplantitis, periodontitis, oral mucositis, and dental pain.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a continuation of U.S. application Ser. No.14/970,322, filed on Dec. 15, 2015, which claims the benefit of U.S.Provisional Application No. 62/092,609, filed Dec. 16, 2014. Each of theabove-referenced patent applications is incorporated by reference in itsentirety.

BACKGROUND OF THE INVENTION Field of the Invention

The present invention relates to cannabinoid oral care compositions,specifically dentifrice in paste and powder form and mouthwash, methodsto prepare the dentifrice and mouthwash, and methods to administer thedentifrice or mouthwash to a human subject. The present invention alsorelates to methods to treat oral infectious conditions using these oralcare compositions.

Description of the Related Technology

Dentifrices are used with toothbrushes to clean and polish teeth. Theycome in powder, paste, liquid, or gel form, the most popular of whichare known as toothpaste and tooth powder, both discussed below. Peoplemainly use dentifrices to prevent dental plaque and remove food debrisafter eating.

Toothpastes are made up of abrasives, binders, surfactants, andhumectants; dentists normally recommend toothpaste that also containsfluoride. While the main purpose of toothpaste is to maintain oralhygiene by cleaning teeth and removing food particles, toothpastes canalso be manufactured to help freshen breath and whiten teeth. Earlytoothpaste began with the Greeks followed by the Romans, which was thenimported into 9th Century Persia. Modern toothpaste began to appear inthe late 19th Century, and fluoride was first added into toothpaste inthe 1890's.

Toothpaste is manufactured typically by first preparing the liquid base,which is made up of water, sorbitol/glycerin, and other liquidingredients. Rheology modifiers may be pre-mixed with a non-aqueousliquid ingredient such as glycerin or flavoring oil, or dry blended withother powder ingredients to aid dispersion. The active ingredients,sweeteners, and preservatives are added and dispersed. The abrasive isthen added, followed by flavoring and coloring agents. Finally, afoaming agent is added under slow speed agitation to avoid foaming.

Tooth powders are manufactured similarly to toothpastes, but without theliquid ingredients, giving only powder as the final product. Otheringredients such as flavoring oils can be added as preferred by themanufacturer.

Dental caries are common infectious diseases affecting billions ofpeople in the world. Dental hygiene, including frequent teeth brushingand use of fluoride-containing dentifrice and/or mouthwash, improvesdental health. Fluoride compounds are commonly added into dentifricesfor anti-bacterial purposes. Fluoride compounds also act to reinforcethe calcium structure of teeth, by inhibiting the initiation of dentalcaries. However, an excessive dosage of fluoride compounds can lead towhite spots on teeth.

Bacteria present in the oral cavity are mostly Streptococcus mutans,Escherichia coli, and Candida albicans. S. mutans infects the throat,causing “strep throat,” E. coli causes digestive tract infections, whileC. albicans promotes dental caries. For these reasons, anti-bacterialtoothpaste is manufactured. Common anti-bacterial toothpaste additivesinclude triclosan and chlorhexidine. There have been some concerns thattriclosan may cause hormone imbalance in animals. Most importantly,anti-bacterial additives are believed to cause anti-bacterial resistantbacteria to spread.

The cannabis plant has many naturally occurring substances that are ofgreat interest in the fields of science and medicine. Isolated compoundsfrom the cannabis plant include Δ⁹-tetrahydrocannabinol (THC),cannabidiol (CBD), cannabichromene (CBC), cannabigerol (CBG),cannabidivarin (CBDV), among other compounds. While THC has psychoactiveeffects, CBD, CBC, CBG, and CBDV do not. Isolated compounds from thecannabis plant are called cannabinoids. There are a total of eighty-five(85) cannabinoids that have been isolated from the cannabis plant. Manyresearchers have confirmed the medicinal value of cannabinoids.Cannabinoids have been investigated for possible treatment of seizures,nausea, vomiting, lack of appetite, pain, arthritis, inflammation, andother conditions.

The IUPAC nomenclature of THC is(−)-(6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol.CBD's IUPAC nomenclature is2-((1S,6S)-3-methyl-6-(prop-1-en-2-yl)cyclo-hex-2-enyl)-5-pentylbenzene-1,3-diol).CBC has the IUPAC nomenclature of2-methyl-2-(4-methylpent-3-enyl)-7pentyl-5-chromenol. These are amongthe most prominent compounds in the family of compounds extracted fromthe cannabis plant referred to as cannabinoids.

Cannabinoids may be isolated by extraction or cold pressing of cannabisplants. Plants in the cannabis genus include Cannabis sativa, Cannabisruderalis, and Cannabis indica. These plants are the natural sources ofcannabinoids. Cannabinoids are also available in synthetic forms.Methods to synthesize cannabinoids in lab settings were discovered andare still currently practiced. Synthetic cannabinoids are more targeted,in that the synthetic compound usually comes isolated without othercannabinoids mixed in.

Nabilone(racemic(6aR,10aR)-1-hydroxy-6,6-dimethyl-3-(2-methyloctan-2-yl)-7,8,10,10a-tetrahydro-6H-benzo[c]chromen-9(6aH)-one),a synthetic cannabinoid, is believed to have fewer undesired sideeffects than THC. Nabilone mimics the chemical compound structure ofTHC. THC also exists in synthetic form under the name Dronabinol((−)-(6aR,10aR)-6,6,9-trimythel-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol)).These synthetic cannabinoids are investigated for medicinal purposes.The U.S. Food and Drug Administration approved nabilone for treatment ofchemotherapy-induced nausea and vomiting. In the United States, nabiloneis marketed under the name Cesamet®. Cannabidiol from hemp is marketedin the United States. Various products containing cannabidiol have beenmarketed in recent years. Cannabidiol may be consumed by ingestion, byinhalation, or by transdermal delivery.

CBD, CBG, and THC have anti-bacterial properties, with fast actingmechanisms. These cannabinoids are anti-bacterial, with a minimuminhibitory concentration at between 0.5-2 μg/ml for variousStaphylococcus aureus strains.

SUMMARY

The present invention is directed at an oral care composition,specifically a dentifrice and a mouthwash solution containing at leastone cannabinoid having anti-bacterial properties. The at least onecannabinoid is present in an amount adequate to give anti-bacterialproperties to the dentifrice; while at the same time is unlikely tocause an overdose of anti-bacterial compounds in dentifrice. The presentinvention also relates to methods to treat oral infectious diseasesusing the dentifrice and/or mouthwash solution comprising cannabinoids.

ABBREVIATIONS

CBC: Cannabichromen

CBDV: Cannabidivarin

CBD: Cannabidiol

CBG: Cannabigerol

IUPAC: International Union of Pure and Applied Chemistry

THC: Tetrahydrocannabinols

W/w: weight/weight

DETAILED DESCRIPTION OF CERTAIN INVENTIVE EMBODIMENTS

This present invention is capable of being embodied in various forms.The description below of several embodiments is made with theunderstanding that the present disclosure is to be considered as anexemplification of the claimed subject matter, and is not intended tolimit the attached claims to the specific embodiments illustrated. Theheadings used throughout this disclosure are provided for convenienceonly and are not to be construed to limit the claims in any way.Embodiments illustrated under any heading may be combined withembodiments illustrated under any other heading.

As used herein, the verb “to comprise” in this description, claims, andother conjugations are used in its non-limiting sense to mean thoseitems following the word are included, but items not specificallymentioned are not excluded.

Reference to an element by the indefinite article “a” or “an” does notexclude the possibility that more than one of the elements are present,unless the context clearly requires that there is one and only one ofthe elements. The indefinite article “a” or “an” thus usually means “atleast one.” Additionally, the words “a” and “an” when used in thepresent document in concert with the words “comprising” or “containing”denote “one or more.”

The word “cannabinoid” used in this description, claims, and otherconjugations is used to mean any compound that interacts with acannabinoid receptor and other cannabinoid mimetics, including, but notlimited to, certain tetrahydropyran analogs (Δ⁹-tetrahydrocannabinol,Δ⁸-tetrahydrocannabinol,6,6,9-trimythel-3-pentyl-6H-dibenzo[b,d]pyran-1-ol,3-(1,1-dimethylheptyl)-6,6a7,8,10,10a-hexahydro-1-1hydroxy-6,6-dimythel-9H-dibezo[b,d]pyran-9-ol,(−)-(3S,4S)-7-hydroxy-delta-6-tetrahydrocannabinol-1,1-dimethylheptyl,(+)-(3S,4S)-7-hydroxy-Δ-6-tetrahydrocannabinol, andΔ⁸-tetrahydrocannabinol-11-oic acid); certain piperidine analogs (e.g.,(−)-(6S,6aR,9R,10aR)-5,6,6a,7,8,9,10,10a-octahydro-6-methyl-1-3-[(R)-1-methyl-4-phenylbutoxy]-1,9-phenanthridinediol1-acetate)); certain aminoalkylindole analogs (e.g.,(R)-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinylm-ethyl)-pyrrolo[1,2,3,-de]-1,4-benzoxazin-6-yl]-1-naphthelenyl-methanone);certain open pyran-ring analogs (e.g.,2-[3-methyl-6-(1-methylethenyl-2-cyclohexen-1-yl]-5-pentyl-1,3-benzendi-ol,and4-(1,1-dimethylheptyl)-2,3′-dihydroxy-6′-α-(3-hydroxypropyl)-1′,-2′,3′,4′,5′,6′-hexahydrobiphenyl),their salts, solvates, metabolites, and metabolic precursors.

The word “cannabidiol” refers to cannabidiol and cannabidiolderivatives. As used in this application, cannabidiol is obtained fromindustrial hemp extract with a trace amount of THC or from cannabisextract using high-CBD cannabis cultivars.

The word “cannabigerol” refers to cannabigerol and cannabigerolderivatives. As used in this application, cannabigerol is derived fromindustrial hemp extract with a trace amount of THC or from cannabisextract.

Toothpaste is manufactured by producing a prewetted binder with ahumectant, and then dispersing the mixture into the liquid phase of theformulation. The entire mixture is mixed in a mixer to form a uniformpaste. Alternatively, the binder is premixed with solid abrasives andthen introduced into a mixing liquid phase of the formulation.

Cannabinoids used in this embodiment may be in liquid form, as a naturalconstituent of hemp oil or cannabis oil. Hemp oil or cannabis oil isharvested by cold pressing the seeds and the plants of the Cannabissativa species. The resulting oil is extracted using CO₂ extraction orsolvent extraction process, and may be further concentrated bydistillation. Choice of cultivars may give different cannabinoidconcentrations, but preferably, the targeted cannabinoids arecannabidiol (CBD) and cannabigerol (CBG). Other cannabinoids such as THCand cannabichromene (CBC) may also be present in hemp oil or cannabisoil. Further isolation of these cannabinoids may result in solid,purified cannabinoids.

In a preferred embodiment, toothpaste is manufactured with one or morecannabinoids incorporated for anti-bacterial effects. In thisembodiment, the one or more cannabinoids are naturally derived orartificially derived.

When cannabinoids are provided as hemp oil or cannabis oil, the hemp oilor cannabis oil may contain up to 85% impurities, including fatty acidsand other plant impurities. The extracted oil is then distilled toincrease the cannabinoid concentration. Impurities in hemp oil andcannabis oil may be fatty acids such as linoleic acid and α-linoleicacid, which are natural components of hemp oil or cannabis oil,β-caryophyllene, myrcene, and β-sitosterol.

In this embodiment, cannabinoids provided as hemp oil or cannabis oilmay contain impurities in an amount of less than 85%, less than 80%,less than 75%, less than 70%, less than 65%, less than 55%, less than50%, less than 45%, less than 40%, or less than 35% by weight.

While many cannabinoids may have anti-bacterial properties, includingΔ⁹-tetrahydrocannabinols, non-psychoactive cannabinoids are preferred inthis invention such that the embodiments may be used by all consumers.It is to be appreciated that psychoactive cannabinoids are includedwithin the scope of the invention in certain embodiments, in cases wherethe psychoactive effect is unimportant.

When the oily form of cannabinoids is used, the viscosity of the oil ishigh, usually in a paste-like matrix. The cannabinoid-containing oil iscombined with a binder and a humectant before introduction into theliquid phase. Alternatively, the cannabinoid oil is premixed with thebinder and a solid abrasive before introduction into the liquid phasefor mixing.

Hemp oil or cannabis oil with naturally occurring cannabinoids may havemore than one cannabinoids. When hemp oil or cannabis oil is used toincorporate cannabinoid into toothpaste, the total cannabinoid contentof the cannabis oil or hemp oil after addition into the toothpaste is at0.1% to 0.5% by weight.

Solid and isolated cannabinoids may also be used. Solid cannabinoids maybe combined with the binder and a humectant before introduction into theliquid phase. Solid cannabinoid(s) may also be mixed with the binder anda solid abrasive prior to introduction into the liquid phase. Solidcannabinoids are present in the toothpaste at 0.1% to 0.5% by weight.

Abrasive agents used in toothpaste manufacturing according to thisembodiment may be hydrated alumina, silica, water-insoluble sodiummetaphosphate, tricalcium phosphate, calcium phosphate dihydrate,anhydrous dicalcium phosphate, calcium pyrophosphate, calcium carbonate,sodium bicarbonate, or aluminum silicate. Commercially availableabrasive agents such as Zeodent 113, Zeodent 115, or Zeodent 116 (silicaabrasive agents) may be used. A combination of abrasive agents may alsobe used. Abrasive agents may be present in this embodiment at between 5%and 15% by weight.

A thickener, such as Zeodent 163, may be used together with othercleansing silica materials to thicken the toothpaste to a desirableviscosity. The thickener is present in the toothpaste at between 2% and15% by weight.

Binders used in toothpaste manufacturing may be chosen from plant gumsuch as guar gum or xanthan gum, sodium alginate, karaya gum, bentonite,carrageenan, blanose cellulose gum, methylcellulose, and PEG-1500. Theamount of binder present in this toothpaste may be at 0.2% to 2.5% byweight.

Humectants may retain water in the toothpaste matrix and keep toothpastefrom drying out. Sorbitol, glycerin, and propylene glycol may be used ashumectants. Glycerin and sorbitol may also give the sweet taste to thetoothpaste as a whole.

Sorbitol may be present in this toothpaste at a 70% aqueous solution. Ina toothpaste composition, sorbitol solution may be present at between25% and 75% by weight of the toothpaste.

Where glycerin is used as a humectant, glycerin may be present atbetween 25% and 75% by weight of the toothpaste. Glycerin has asweetness of about 60% that of table sugar and additional sweeteners maybe added to improve the toothpaste's taste.

The toothpaste according to this embodiment may have one or morefluoride compounds to prevent dental caries. Suitable fluoride compoundsmay be sodium monofluorophosphate and sodium fluoride. The fluoridecompound may be present in the toothpaste at 0.1% to 1% by weight.

In the toothpaste, the one or more cannabinoids may be present at 0.1%to 0.5% by weight, more specifically at 0.2% to 0.4% by weight. Fornaturally derived cannabinoids, wherein the hemp oil or cannabis oil hasmultiple cannabinoids, at least one cannabinoid may be present tocomprise between 0.1% and 0.5% by weight of the toothpaste. Forartificially derived cannabinoids, adding one isolated purifiedcannabinoid, preferably chosen from the group comprising of CBD, CBG,THC and CBC, is recommended. The amount of the artificial cannabinoidmay be at 0.1% to 0.5% by weight of the toothpaste.

Lactoferrin may be added into the toothpaste in this embodiment at 0.1%to 0.5% by weight. Lactoferrin attacks biofilm bacteria and works as awound dressing agent to speed up wound healing. In the oral cavity,biofilm bacteria are a major concern.

Anti-inflammation agents may be added into the toothpaste at 0.2% to0.6% by weight. Magnesium sulfate has anti-inflammation properties aswell as coagulant properties to stop bleeding, and may be added into thetoothpaste according to this embodiment.

Foaming agents or surfactants may be added to toothpaste to create thefoam appearance during brushing. Surfactants such as sodium laurylsulfate, sodium lauryl sulfoacetate, dioctyl sodium sulfosuccinate,sulfolaurate, sodium lauryl sarcosinate, sodium stearyl fumarate, andsodium stearyl lactate may be added into the toothpaste. Commerciallyavailable foaming agents such as cocamidopropyl betaine (available asTego Betain ZF, sold by Evonik Industries AG Personal Care) may also beused as surfactants.

Other components of the toothpaste may be used in sufficient amounts,including water, other preservatives, sweeteners, and flavoring oils.

Flavoring oils as used this embodiment may be wintergreen, peppermint,spearmint, cinnamon, orange, watermelon, citrus, peach, apricot, anise,vanilla, clove, green tea, caraway, eucalyptus, sage, thyme, bourbon,rye, or any suitable flavors. Multiple flavors may be added.

Coloring agents to give the toothpaste a desirable color may be added.Popular colors are white, blue, red, orange, and green. Coloring agentsmay be present in the toothpaste at 1% to 3% by weight.

Preservatives suitable for food products may be added into thetoothpaste. Suitable preservatives include citric acid, trisodiumcitrate, alcohols, benzoates, and dichlorinated phenols. Citric acid andcitrates are preferred preservatives. Preservatives may be present at0.05% to 2% by weight.

Abrasive agents, humectants, binders, and cannabinoids may be combinedand mixed in a container, forming the first phase. The liquid phase, orthe second phase, including water, fluoride compounds, preservatives,coloring agents, sweeteners, and flavoring oils, may be combined andmixed. Then, the first phase may be mixed into the second phase andstirred well with a propeller. Temperature control to keep the mixturefrom drying out is desirable.

In another embodiment of this invention, tooth powder with cannabinoidsadded for anti-bacterial purposes is disclosed. Tooth powder may be usedin the same manner as toothpaste. Tooth powder contains similaringredients with toothpaste, but without water and binders.

In this embodiment, solid isolated cannabinoid(s) may be used in themanufacturing of dentifrices. Isolated cannabinoids may be in finepowder form and may be effective when combined into dentifrice powder.Grain size may be modified and adjusted to avoid sieving effects andseparation of grains within the dentifrice powder.

In this embodiment, the tooth powder may contain one or more abrasiveagents. The one or more abrasive agent may be chosen from a groupcomprising of baking soda, chalk, clay, activated carbon, or pumicepowder.

One or more cannabinoids in powder form may be added into the toothpowder in this embodiment. One or more cannabinoids may be present inthe tooth powder at 0.05% to 0.3% by weight.

Preferably, the cannabinoids added to tooth powder may be derived fromnatural sources. Hemp oil or cannabis oil with naturally occurringcannabinoids may be freeze dried, or granulated and purified, and theresulting powder, which is high in cannabinoids, may be added into toothpowder at 0.05% to 0.5% by weight.

Synthetic cannabinoids may also be added into tooth powder. Syntheticcannabinoids are typically in powder form and mix well into toothpowder. The proportion of synthetic cannabinoids added may be at 0.05%to 0.5% by weight.

The tooth powder may further comprise a sweetener for taste improvementpurposes. Xylitol is the preferred sweetener as it is available inpowder form and does not cause dental caries. Saccharin may also beused, but due to its strong sweet taste, the proportion added should below. The proportion of the sweetener is according to taste, butpreferably at 0.5% to 10% by weight of the tooth powder.

The tooth powder may further comprise other additives for flavor, suchas sage, spearmint, peppermint essential oil, wintergreen essential oil,lemon oil, orange oil, anise oil, or cinnamon oil. Flavors are availablein essential oil and may be combined into the tooth powder by mixing.

Components of the tooth powder according to this embodiment are mixed bya solid mixer for even distribution.

The toothpaste or tooth powder according to these embodiments is used byplacing a sufficient quantity on a toothbrush. A human subject appliesagitating force to his or her teeth using the toothbrush with thetoothpaste or tooth powder. The human subject rinses his or her mouthwith drinking water.

In another embodiment of this invention, a mouthwash solution comprisingcannabinoids is provided. This cannabinoid mouthwash solution may haveanti-bacterial properties and inhibits growth of harmful bacteria in theoral cavity.

In this embodiment, one or more cannabinoids may be added as isolatedcannabinoids, either naturally or artificially derived. Isolatedcannabinoids are in powder form and requires relatively smalleremulsifying capacity when mixed into a water/ethanol solution.Cannabinoids provided as hemp oil or cannabis oil may be incorporated,but preferably with higher emulsification load. The resulting mouthwashsolution using hemp oil or cannabis oil may separate.

Cannabinoids as used in this embodiment are THC, CBD, and CBG,preferably CBD and CBG. A combination of different cannabinoids may beused in this embodiment. Cannabinoids are present in this embodiment at0.5% to 4% by weight of the mouthwash solution.

If hemp oil or cannabis oil with high cannabinoid concentration is used,the total cannabinoid content added may be present at 0.5% to 4% byweight of the mouthwash. When hemp oil or cannabis oil is used, acombination of cannabinoids may be present.

The mouthwash solution may include surfactants. Suitable nonionicsurfactants may be poly-ethoxylated sorbitol esters, polycondensates ofethylene oxide and propylene oxide, poly-ethoxylated hydrogenated castoroil (available as Eumulgin HRE40, sold by BASF). Suitable anionicsurfactants are sodium dodecyl sulfate (sodium laurylsulfate), sodiumlaureth sulfate, sodium lauroyl sarcosinate, and potassium laurylsulfate. Suitable amphoteric surfactants include, for example, longchain imidazoline and long chain alkyl betaines. Suitable cationicsurfactants include D,L-2-pyrrolidone-5-carboxylic acid salt ofethyl-N-cocoyl-L-alginate and cocamidopropyl PG dimonium chloridephosphate. Surfactants may be present in this embodiment at 0.5% to 10%(w/w), more preferably at 0.5% to 5% (w/w).

The mouthwash solution may further include thickeners. Suitablethickeners may be methylcellulose, hydroxyalkylcellulose ethers,alkylcellulose ethers, hydroxypropyl methylcellulose, gum tragancanth,sodium carboxymethylcellulose, blanose cellulose gum (available asBlanose 7LF, sold by Ashland), polyvinyl pyrrolidone (available asPlasdone C-30, sold by Ashland), and carrageenan. Thickeners also act asemulsifiers to promote mixing in the suspension. The thickening agentmay be present in the mouthwash solution at 0.5% to 5% (w/w).

The mouthwash solution preferably further comprises a humectant.Humectants retain water and prevent the solution from drying out.Suitable humectants may be chosen from a group comprising of glycerine,sorbitol, propylene glycol, and polyethylene glycol. A combination ofmore than one humectants may also be used. Humectants may be present inthe mouthwash solution at 2% to 10% (w/w).

The mouthwash may further include cavity prevention and/orre-mineralization agents. Suitable cavity prevention or remineralizationagents may be sodium monofluorophosphate and sodium fluoride. The cavityprevention agent may be present in the mouthwash solution at 0.01% to0.5% (w/w).

The mouthwash according to this embodiment may further comprise anadditional anti-bacterial agent such as lactoferrin. Lactoferrin attacksbiofilm bacteria and acts as a wound-dressing agent to promote healing.

The mouthwash according to this embodiment may further comprise at leastone flavor. Flavors as used this embodiment may be wintergreen,peppermint, spearmint, cinnamon, orange, watermelon, citrus, peach,apricot, anise, vanilla, clove, green tea, caraway, eucalyptus, sagethyme, bourbon, rye, or any suitable flavors. Multiple flavors may beadded.

Coloring agents to give the mouthwash a desirable color may be added.Popular colors may be white, blue, orange, gold, and green. Coloringagents may be present in the mouthwash at 1% to 3% by weight.

Preservatives suitable for food products may be added into the mouthwashaccording to this embodiment. Suitable preservatives include citricacid, trisodium citrate, alcohols, sodium paraben, benzoates, anddichlorinated phenols. Preservatives may be present at 0.05% to 2%(w/w).

The mouthwash solution may have an aqueous base comprising water andethanol. Ethanol increases solubility of powder cannabinoids. Ethanolmay be present in this mouthwash at 5% to 20% (w/w).

The mouthwash solution may be used by a mammal, preferably a humanbeing, by placing an appropriate amount of the mouthwash in the humansubject's mouth, the human subject holds the mouthwash in the oralcavity for at least thirty (30) seconds, and the human subject spits themouthwash out.

Various oral infectious diseases may be treated with cannabinoid oralcare solutions due to their antibacterial, pain relieving, wounddressing, and anti-inflammation properties. Conditions treated by thesecannabinoid oral care compositions may include periimplantitis,periodontitis, oral mucositis (especially oral mucositis caused bychemotherapy in cancer treatment), and dental pain.

Cannabinoid dentifrice, including cannabinoid toothpaste and cannabinoidtooth powder, may be used in teeth brushing at a therapeuticallyeffective amount to treat periimplantitis, periodontitis, oralmucositis, and dental pain.

Cannabinoid mouthwash may be used in conjunction with, or separatelyfrom, cannabinoid dentifrice. A therapeutically effective amount ofcannabinoid mouthwash may be held in the oral cavity of a human subjectfor at least thirty seconds before spitting out for treatment ofperiimplantitis, periodontitis, oral mucositis, and dental pain.

EXAMPLES Example 1

This formulation makes 3000 grams of toothpaste. All ingredients areobtained and weighed according to Table 1.

The following ingredients are obtained: Glycerin 99% Ph Eur bySigma-Aldrich, trisodium citrate.2aq Ph Eur by Sigma-Aldrich, PEG-1500by Sigma-Aldrich, Zeodent 113 (abrasive agent) and Zeodent 163(thickener) by Huber Engineered Materials, Tego Betain ZF (foamingagent) by Prospector, Blanose CMC 12M31XP (binder) by Ashland.

Other ingredients are purified water, FD&C Blue No. 1 (0.2% solution)for coloring, methyl salicilate (wintergreen flavor), Flavor RV35640(peppermint flavor), sodium methylparaben (preservative), citric acid(preservative), saccharine (flavor), xylitol (cavity prevention),magnesium sulfate7.aq (anti-inflammation agent), sodium fluoride(remineralized agent), hemp oil with 3% w/w CBD and 17% w/w CBG(anti-bacterial agent, wound dressing agent), lactoferrin(anti-bacterial agent, wound dressing agent).

TABLE 1 Ingredients for cannabinoid toothpaste Raw Material % (w/w)Weight (g) Glycerine 99% Ph Eur 56.0800 1682.4000 Water 15.0000 450.0000FD&C Blue No. 1 (0.2%-solution) 2.0000 60.0000 Methyl salicilate 0.20006.0000 Sodium methylparaben 0.1500 4.5000 Citric acid 0.0800 2.4000Saccharine 0.2500 7.5000 Xylitol 0.2500 7.5000 Tri-Sodium Citrate•2 aqPh Eur 0.3400 10.2000 Magnesium Sulfate•7 aq 0.4300 12.9000 Sodiumfluoride 0.2200 6.6000 Hemp oil CBD/CBG (3%/17%) 2.0000 60.0000 Zeodent113 8.0000 240.0000 Zeodent 163 8.0000 240.0000 Flavor RV35640Peppermint 1.5000 45.0000 Tego Betain ZF 3.0000 90.0000 BlanoseCMC12M31XP 0.5000 15.0000 PEG 1500 1.7500 52.5000 Lactoferrin 0.25007.5000 Total 100.0000 3000.0000

Stage 1: 450 grams of water are placed in the main mixer.

Stage 2: 15 grams of Blanose CMC 12M31XP, 240 grams of Zeodent 113 andZeodent 163 each, and 60 grams of hemp oil (CBD/CBG 3%/17% w/w)) are drymixed in a different vessel, then added into the main mixer. The mainmixer mixes for 10 minutes and produces a cream-like paste.

Stage 3: In a different vessel, mix 1200 grams of the glycerin solution,saccharine, sodium fluoride, sodium methylparaben, xylitol, citric acid,trisodium citrate.2aq Ph Eur, magnesium sulfate. 7aq, PEG 1500, andlactoferrin. The vessel is heated to increase dissolution. This mixtureis added into the main mixer and mixed for 15 minutes.

Stage 4: A mixture of Tego Betain ZF and the rest of the glycerinsolution is added into the main mixer and mixed for 15 minutes.

Stage 5: Methyl salicilate and peppermint flavor are added into the mainmixer and mixed for another 10 minutes. The toothpaste is then packedinto tubes or pump containers.

Example 2

This formulation makes 100 grams of tooth powder.

TABLE 2 Ingredients for cannabinoid tooth powder Raw Material % (w/w)Weight (g) Baking soda 39.7000 39.7000 Clay 30.0000 30.0000 Cannabidiol(powder) 0.1000 0.1000 Cannabigerol (powder) 0.2000 0.2000 Xylitol20.0000 20.0000 Peppermint oil 10.0000 10.0000 Total 100.0000 100.0000

Weigh and combine baking soda, clay, cannabidiol, and xylitol accordingto the weight percentage given above. Mix well in a solid mixer; thenadd 10 grams of peppermint oil and mix for another 5 minutes. Theresulting tooth powder is packaged into jars.

Example 3

This formulation makes 1000 g of mouthwash

TABLE 3 Ingredient for cannabinoid mouthwash Raw material % (w/w) Weight(g) Water 81.010 810.100 Ethanol 10.000 100.000 Glycerine 99% Ph Eur3.000 30.000 Blanose 7LF 0.300 3.000 Tri-Sodium Citrate•2 aq Ph Eur0.340 3.400 Sodium methylparaben 0.150 1.500 Xylitol 0.100 1.000Magnesium Sulfate•7 aq 0.050 0.500 Plasdone C-30 1.000 10.000 CBD/CBG(3%/17%) 0.060 0.600 CBG 0.340 3.400 Lactoferrine 0.200 2.000 Sodiumlaurylsulfate 1.000 10.000 Eumulgin HRE40 1.500 15.000 Sodium fluoride0.050 0.500 Methyl salicilate 0.100 1.000 Flavor RV35641 Peppermint0.300 3.000 Citric acid 0.500 5.000 Total 100.0000 1000.0000

All ingredients are obtained according to the list above. Mix allingredients except for water and ethanol in a stainless steel containerwhile mixing with a propeller. Add ethanol while continue to mix, thenadd water. The mixture is mixed for another 30 minutes. This formulamakes 1000 g of mouthwash.

Variations and modifications will occur to those of skill in the artafter reviewing this disclosure. The disclosed features may beimplemented, in any combination and sub-combination (including multipledependent combinations and sub-combinations), with one or more otherfeatures described herein. The various features described or illustratedabove, including any components thereof, may be combined or integratedin other systems. Moreover, certain features may be omitted or notimplements.

Examples of changes, substitutions, and alterations are ascertainable byone skilled in the art and could be made without departing from thescope of the information disclosed herein. All references cited arehereby incorporated by reference herein in their entireties and madepart of this application.

What is claimed is:
 1. A cannabinoid toothpaste composition comprising:(a) at least one abrasive agent selected from the group consisting ofabrasive silica, hydrated alumina, water-insoluble sodium metaphosphate,tricalcium phosphate, calcium phosphate dihydrate, anhydrous dicalciumphosphate, calcium pyrophosphate, calcium carbonate, sodium bicarbonate,and aluminum silicate; (b) at least one binder selected from the groupconsisting of guar gum, xanthan gum, sodium alginate, karaya gum,bentonite, carrageenan, blanose cellulose gum, and methylcellulose; (c)at least one humectant selected from the group consisting of sorbitolsolution, glycerin solution, and propylene glycol; (d) at least onefluoridating agent; (e) at least one surfactant selected from the groupconsisting of sodium lauryl sulfate, sodium lauryl sulfoacetate, dioctylsodium sulfosuccinate, sulfolaurate, sodium lauryl sarcosinate, sodiumstearyl fumarate, and sodium stearyl lactate; (f) water; (g) athickener; (h) lactoferrin; and (i) one or more cannabinoids; whereinthe one or more cannabinoids is present in an amount of 0.1 to 0.5weight percent, and wherein lactoferrin is present in an amount of 0.1to 0.5 weigh percent.
 2. The cannabinoid toothpaste of claim 1, whereinthe one or more cannabinoids is provided as a natural constituent ofhemp oil or cannabis oil.
 3. The cannabinoid toothpaste of claim 1,further comprising one or more anti-inflammation agents.
 4. Thecannabinoid toothpaste of claim 3, wherein the anti-inflammation agentis magnesium sulfate.
 5. The cannabinoid toothpaste of claim 3, furthercomprising one or more coloring agents.
 6. The cannabinoid toothpaste ofclaim 5, further comprising a sweetener.
 7. The cannabinoid toothpasteof claim 6, further comprising one or more preservatives selected fromthe group consisting of citric acid, trisodium citrate, alcohols,benzoates, and dichlorinated phenols.
 8. The cannabinoid toothpaste ofclaim 7, further comprising at least one flavor selected from the groupconsisting of spearmint, peppermint, wintergreen, cinnamon, orange,watermelon, citrus, peach, apricot, anise, vanilla, clove, green tea,caraway, eucalyptus, sage, thyme, bourbon, and rye.